[sdpd] Vacancy at ESRF - Powder Diffraction

[Armel Le Bail <alb...@cristal.org>]

Elizabeth MOULIN / Bénédicte HENRY CANUDAS
Recruitment Officers

Tel.:   +33 (0)4 76 88 28 27 / 25 82
Fax:    +33 (0)4 76 88 24 60
E-mail: <mailto:recruitm...@esrf.fr>recruitm...@esrf.fr
Web:    http://www.esrf.fr


*************************************************************
REF. CFR318

The ESRF is a multinational research institute, situated in Grenoble, 
France and financed by 18 countries mostly European. It operates a powerful 
synchrotron X-ray source with some 30 beamlines (instruments) covering a 
wide range of scientific research in fields such as biology and medicine, 
chemistry, earth and environmental sciences, materials and surface science, 
and physics. Research at the ESRF is carried out by several thousand 
external users each year from universities, public research laboratories 
and industry, and by the ESRF's own scientists. The ESRF employs about 
600staff and is organized as a French société civile. The working language 
of the ESRF is English.

The Experiments Division designs, constructs and runs the ESRF experimental 
stations (= beamlines). Within this division the Materials Science group is 
now seeking to recruit a:

PhD Thesis Student (m/f)
Subject: Powder diffraction studies on proteins

General Framework:
Diffraction is amongst the most important methods for obtaining information 
about the structure of proteins and thereby gain insight into fundamental 
biological and biochemical mechanisms. Normally it is necessary to grow a 
single crystal, which requires considerable skill and patience. Recently, 
it has been shown that analysis of high quality powder diffraction data can 
yield some structural information about microcrystalline proteins. A 
crystalline powder is usually easier to produce than a single crystal, so 
the powder diffraction method is showing potential as a complementary tool 
to the established approach.

Description of the thesis work:
The project will develop and apply powder diffraction techniques to protein 
crystallography using the X-ray beams at the ESRF. In addition to assessing 
the optimum data-collection strategies for such studies, a series of 
microcrystalline samples of native and derivative proteins will be 
investigated, concentrating on: (a) the detection of protein-ligand complex 
formation under a variety of conditions; (b) phase diagram mapping and 
characterization of different polymorphs; (c) structure solution via well 
recognized techniques in protein crystallography (e.g. molecular 
replacement, single/multiple isomorphous replacement, etc.).

Place of Work:  ESRF in Grenoble
Supervisor:     Andy FITCH (email: <mailto:fitch...@esrf.fr>fitch...@esrf.fr) and 
Irene MARGIOLAKI (<mailto:margiolaki...@esrf.fr>margiolaki...@esrf.fr)
General Conditions:
You should hold a degree in a science subject allowing enrolment for a PhD, 
such as an MSc, Master 2 de Recherche, Laurea or equivalent. Contract of 
two years renewable (subject to satisfactory progress) for one year. Gross 
salary around 2081 ¬/month. The applicant will be responsible for arranging 
his/her academic registration and for paying the fees (if any).
If you are interested, please send us a fax (+33 (0)4 76 88 24 60) or an 
e-mail (<mailto:recruitm...@esrf.fr>recruitm...@esrf.fr) with your address, and 
we will provide you with an application form. Or print out an application 
form on the World Wide Web http://www.esrf.fr/. In addition to the 
application form, you should provide us with a detailed CV and the names of 
two referees.

Deadline for returning the application forms: 15 January 2007

All applications received after the deadline may be considered for the 
selected vacancy if not filled or for future similar positions.



 
Yahoo! Groups Links

<*> To visit your group on the web, go to:
    http://groups.yahoo.com/group/sdpd/

<*> Your email settings:
    Individual Email | Traditional

<*> To change settings online go to:
    http://groups.yahoo.com/group/sdpd/join
    (Yahoo! ID required)

<*> To change settings via email:
    mailto:sdpd-digest...@yahoogroups.com 
    mailto:sdpd-fullfeatured...@yahoogroups.com

<*> To unsubscribe from this group, send an email to:
    sdpd-unsubscribe...@yahoogroups.com

<*> Your use of Yahoo! Groups is subject to:
    http://docs.yahoo.com/info/terms/