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[sdpd] UPPW-6 solutions - UPPW-7 problem - Last of the year...



Hello,

Well, Alan, 100s of data to index would put us on our
knees. Doing it automatically would force all software
to have an automatic mode. You want to transform the
"art of indexing" into an industrial process ;-). Quite
logical for you but most powder diffractionists have less
than 10 powder patterns to index per year. Let us believe
that we can perform better than automatic systems...

The solutions for UPPW-6 are similar for all participants.
        http://www.cristal.org/uppw/uppw6.html

The UPPW-7 will be the last of the 2003 year (I will not
be able to ensure the job till 2004). So you have one
month for solving it...

Meantime, Peter Stephens could obtain the sample
and record a synchrotron pattern (given that it is an
antimalarial drug, you may feel more concerned) ?

http://www.cristal.org/uppw/uppw7.html

UPPW-7
November 28, 2003

Problem :

ICDD 51-1948
C16H26O5   alpha-Methyldihydroartemisinine
Wavelength   1.5406 A
Filter : mono
Ref : L. Chen, Inst. of Precious Metals, Kunming,
P.R. China, Private Communication (1998)

Pattern taken at room temperature.
Sample provided by C. Wang, Kunming Pharmaceutical Corp.,
P.R. China.
CAS #: 71963-77-4.
Also called alpha-artemether
Mwt : 298.38

d(A)  intensities
8.716 100
8.410  47
7.688   7
6.959  26
6.722  20
5.793   7
5.590   8
5.254   8
5.151   9
4.921  97
4.761  42
4.647  24
4.502  14
4.345  16
4.261   8
3.927  19
3.689   5
3.466   3
3.314   7
3.123   8
3.009   2
2.897   3
2.792   6
2.727   4
2.690   4
2.506   3
2.241   3
2.174   2
2.151   3
2.048   2


NOTE :

The structure of a C16H26O5 (arthemeter), antimalarial drug, is
described in the Cambridge Structural Database. Apparently a different
polymorph. Below are the d(hkl) calculated by HKLGEN :

  Artemether 
CSD
   WAVELENGTH 1.54060
   SPACE GROUP : P 21
  A=  9.8680      B= 18.3240      C= 10.1720
  ALPHA= 90.000   BETA=117.550    GAMMA= 90.000   VOL = 1630
     H   K   L  MULT   d(A)    2-theta(°)
     0   2   0   2    9.1620     9.646
     0   0   1   2    9.0186     9.800
     1   0   0   2    8.7490    10.102
     1   0  -1   2    8.5638    10.321
     0   1   1   4    8.0916    10.925
     1   1   0   4    7.8953    11.198
     1   1  -1   4    7.7583    11.396
     0   2   1   4    6.4272    13.767
     1   2   0   4    6.3275    13.985
     1   2  -1   4    6.2563    14.145
     1   0   1   2    5.1930    17.061
     1   0  -2   2    5.0770    17.454
     0   3   1   4    5.0573    17.522
     1   3   0   4    5.0083    17.695
     1   1   1   4    4.9962    17.738
     1   3  -1   4    4.9728    17.822
     2   0  -1   2    4.9324    17.969
     1   1  -2   4    4.8927    18.117
     2   1  -1   4    4.7629    18.615
     0   4   0   2    4.5810    19.361
     1   2   1   4    4.5177    19.634
     0   0   2   2    4.5093    19.672
     1   2  -2   4    4.4408    19.978
     0   1   2   4    4.3787    20.265
     2   0   0   2    4.3745    20.284
     2   2  -1   4    4.3430    20.433
     2   0  -2   2    4.2819    20.727
     2   1   0   4    4.2550    20.860
     2   1  -2   4    4.1696    21.292
     0   4   1   4    4.0843    21.742
     1   4   0   4    4.0583    21.883
     0   2   2   4    4.0458    21.952
     1   4  -1   4    4.0394    21.987
     1   3   1   4    3.9563    22.454
     2   2   0   4    3.9476    22.505
     1   3  -2   4    3.9043    22.757
     2   2  -2   4    3.8792    22.907
     2   3  -1   4    3.8374    23.160
     0   3   2   4    3.6278    24.518
     2   3   0   4    3.5565    25.018
     2   3  -2   4    3.5062    25.383

Best wishes,

Armel

PS - Victor Zlokazov has sent solutions of the previous
UPPWs by using AUTOX. These results have been added
to the solution files, see :
http://www.cristal.org/uppw/list.html



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