[sdpd] Workshop Announcement

[Armel Le Bail <armel...@fluo.univ-lemans.fr>]

Found at ESRF :

Powder Diffraction on Pharmaceuticals   -  29 March 2000

http://www.esrf.fr/industry/wksp/ind_wksp.html

The European Synchrotron Radiation Facility offers industrials new possibilities
 for the characterization of solid states properties using X-ray powder diffraction.
 The high brightness and high resolution of the ESRF beams allow more
 information to be extracted from powder diffraction data (XRPD) than when using
 a classic X-ray laboratory source.
 Concerning pharmaceutical applications, this technique allows in particular the
 study of crystalline forms of new compounds (polymorphs and
 pseudopolymorphs) which may be very useful for preformulation research,
 analytical research, and the assurance of product quality and safety.
                                                                         
                                                                                                
       
                         Applications for Pharmaceutical Compounds

The powder diffraction set-up at the ESRF permits the measurement of the "optimum" high resolution data for:

            Solving crystal structure
            Quantitative phase analysis
            Crystallite size and residual microstrains
            Follow-up of crystal structure changes with the action of
              physico-chemical parameters: temperature, pressure, pH, degree of hydration 
              processes: after miling, (wet)granulation,drying, grinding, tableting 

The study of polymorphism and pseudopolymorphism can be carried out at
the ESRF with a high sensitivity. Very similar diffraction patterns from two
polymorphs can be differentiated .
Once solved, the crystal structure provides the information necessary to
understand the relationship between the structure and the physical properties
of pharmaceutical compounds : flow, hygroscopicity, dissolving rate, solubility.
       
During this meeting, ESRF scientists will expose practice cases with
diffraction patterns of pharmaceuticals and experiments concerning
problems of polymorphism. 

       

      PROGRAMME
      10.00 - 10.30
                     Presentation of the ESRF
                                                                 Dr P.F. Lindley
                                                                 Research Director
      10.30 - 11.30
                     Powder diffraction on pharmaceuticals at the ESRF
                                                                 Dr A. Kvick
                                                                 Head of Diffraction Group
                                                                 Dr A. Fitch
                                                                 Beamline responsible
      11.30 - 12.30
                     Guided tour of the facilities
                                                                  
      12.45 - 14.00
                     Lunch
                                                                  
      14.00 - 14.30
                     Various Access modes to the ESRF facilities: Service
                     for powder diffraction
                                                                 Dr J. Doucet
                                                                 Industrial Co-ordinator
      14.30 - 16.00
                     Informal discussions with ESRF scientists